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Updated: Feb 19, 2026

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贝塞特病与与怀孕相关的结果之间的关联:系统性审查和元分析

Kai-Wen Chuang¹, Ching-Yu Wang², Buo-Jia Lu³

¹Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.

Journal of reproductive immunology

|February 17, 2026

概括

患有贝塞特病 (BD) 的女性怀孕显著增加了母亲和胎儿并发症的风险,包括血块,流产和胎儿生长限制. 多学科护理对于优化这些高风险怀孕的结果至关重要.

科学领域:

类风湿病学类风湿病学
产科产科产科产科产科
遗传学是一个遗传学.

背景情况:

贝切特病 (Behçet disease,简称BD) 是一种慢性自身炎症性疾病,导致全身性血管炎.
它不成比例地影响生育年龄的女性,造成怀孕并发症的风险.

研究的目的:

评估贝希特病对孕产妇,产科和胎儿健康状况的影响.
综合关于BD妇女怀孕相关风险的证据.

主要方法:

在主要数据库 (PubMed,Scopus,Web of Science,Cochrane Library) 进行系统的文献搜索,截至2025年1月.
七个队列研究的元分析,涉及498个BD怀孕和超过1400万对照.
随机效应模型用于计算Mantle-Haenszel风险比率 (MH RRs) 的95%置信区间 (CI).

主要成果:

患有BD怀孕的孕妇患血栓栓塞事件 (MH RR = 19.48),流产 (MH RR = 2.74),剖腹产 (MH RR = 1.44),胎儿生长限制 (MH RR = 2.37) 和胎儿异常 (MH RR = 2.01) 的风险显著增加.
患有BD的亚洲女性患有妊娠糖尿病的风险更高 (MH RR = 3.61).

结论:

患有贝塞特病的孕妇面临着严重增加的母亲和胎儿不良后果的风险.
强调需要专门的,多学科的护理,以改善BD怀孕的管理和结果.

关键词:

贝希特病是贝希特病的一种疾病.剖腹产是一个剖腹产.胎儿的异常胎儿的异常胎儿生长限制胎儿生长限制流产流产流产血栓栓塞栓事件发生.

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