相关实验视频

Updated: Feb 19, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

鉴定和实验证实TBC1D10C作为腹腔大动脉动脉瘤和严重抑郁症之间共享的转录联系

Chen Dong¹, Jianhua Xie¹, Rui Shen¹

¹Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Engineering Research Center for Immunological Diagnosis and Therapy of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Biochemical and biophysical research communications

|February 17, 2026

概括

腹腔大动脉动脉瘤 (AAA) 和主要抑郁症 (MDD) 分享免疫失调路径. TBC1D10C是关键调节剂,在两种条件下下调节,这表明它是潜在的双重治疗标.

科学领域:

免疫学免疫学免疫学
遗传学是一个遗传学.
心血管研究研究心血管研究
精神病学是一个精神病学.

背景情况:

腹腔大动脉瘤 (AAA) 和严重抑郁症 (MDD) 是全球重要的健康问题.
有证据表明,共享的免疫失调和炎症是这两种疾病的基础.
识别共同的分子通路可能会导致统一的治疗策略.

研究的目的:

为了确定AAA和MDD之间共享的分子通路.
为了阐明它们的共同病原性.
发现具有双重相关性的新型治疗点.

主要方法:

整合了七个基因表达数据集.
利用差异表达和加权基因共同表达网络分析.
使用机器学习,scRNA-seq和小鼠模型验证了关键基因.

主要成果:

确定了100个共享基因,其中TBC1D10C作为一个关键的枢纽基因.
TBC1D10C表达局部化到免疫细胞,与淋巴细胞激活相反相关.
在AAA和MDD的小鼠模型中观察到下调的TBC1D10C.

结论:

在AAA和MDD中,TBC1D10C是关键调节器.
它的下调与增加的淋巴细胞激活和炎症相关.
对于这两种情况,TBC1D10C是潜在的治疗标.

关键词:

腹腔大动脉动脉瘤腹腔大动脉动脉瘤生物信息学是一种生物信息学.炎症炎症是一种炎症.淋巴细胞淋巴细胞大型抑郁症主要是抑郁症.单细胞RNA测序的一个细胞.

更多相关视频

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

相关概念视频

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...