相关实验视频

Updated: Feb 19, 2026

Collecting Hair Samples for Hair Cortisol Analysis in African Americans

Collecting Hair Samples for Hair Cortisol Analysis in African Americans

Published on: June 10, 2018

调查内源性高皮质醇症在美国人口中患有抗性高血压的患病率:MOMENTUM推理和设计

Jorge Plutzky¹, Pam R Taub², Deepak L Bhatt³

¹Brigham and Women's Hospital, Boston, Massachusetts, USA.

|February 17, 2026

概括

这项MOMENTUM研究调查了成年人患有抗性高血压 (rHTN) 的内源性高皮质醇症. 这项研究旨在确定这种疾病在大量患者群体中的患病率.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
临床研究临床研究

背景情况:

高血压是心血管疾病和死亡的主要危险因素.
抗性高血压 (rHTN) 影响高血压成人高达18%,增加不良结果.
内源性高皮质醇是通过多种机制导致rHTN的潜在原因.

研究的目的:

这项MOMENTUM研究是美国第一个大型的观察性多中心试验,旨在评估rHTN成年人内源性高皮质醇症的患病率.
调查内源性高皮质醇和抗性高血压之间的联系.
为耐性高血压患者的病情提供新的见解.

主要方法:

招募大约1000名成年参与者 (≥18岁) 患有抗性高血压 (rHTN).
根据美国心脏协会标准定义的rHTN:SBP ≥130 mm Hg尽管服用了≥3种抗高血压药物 (包括在最大耐受剂量下,或≥4种药物,无论SBP.
内源性高皮质醇症诊断为皮质醇>1.8μg/dL在1mg夜间德甲抑制试验 (DST) 中,具有足够的德甲水平 (≥140 ng/dL).

主要成果:

主要终点是研究人口中内源性高皮质醇症的患病率.
数据收集正在进行中;研究完成后将公布结果.
预计将揭示显著的流行数据.

结论:

这项MOMENTUM研究将为耐性高血压患者队列中的内源性高皮质醇症提供新的见解.
预计这些发现将为临床实践和未来的研究方向提供信息.
了解这种联系对于管理复杂的高血压病例至关重要.

关键词:

皮质醇是一种皮质醇.德克萨米他抑制试验内源性高皮质醇主义 (hypercortisolism) 是一种患病率的流行情况.抗性高血压是一种抗性高血压.

更多相关视频

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

Published on: July 10, 2017

Extraction and Analysis of Cortisol from Human and Monkey Hair

Extraction and Analysis of Cortisol from Human and Monkey Hair

Published on: January 24, 2014

相关概念视频

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...

Hypertension II: Pathophysiology

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

Hypertension and Regulation of Blood Pressure

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...

Hypertension I: Introduction

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...

Adrenal Gland Disorders

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...

Hypertension IV: Drug Therapy and Lifestyle Modifications

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...