在器官移植中实施数字双胞胎技术:概念,新兴证据和临床翻译途径
David B Olawade1, Aderonke Odetayo2, Eghosasere Egbon3
1Department of Allied and Public Health, School of Health, Sport and Bioscience, University of East London, London, United Kingdom; Department of Research and Innovation, Medway NHS Foundation Trust, Gillingham ME7 5NY, United Kingdom; Department of Public Health, School of Business and Health Studies, York St John University, London, United Kingdom.
Transplantation reviews (Orlando, Fla.)
|February 17, 2026
概括
数字双胞胎通过创建动态的患者复制品,在移植中提供个性化的精密医学. 这些工具有助于捐赠者评估,器官保存和终身免疫管理,有望改善移植结果.
科学领域:
- 数字健康数字健康
- 计算生物学是一种计算生物学.
- 精准医学是一门精准的医学.
背景情况:
- 数字双胞胎是患者或器官的数据驱动的计算复制品,随着实时信息的演变而发展.
- 移植是数据丰富的领域,由于复杂的免疫管理和时间关键的决策,它非常适合精密医学.
研究的目的:
- 审查整个移植生命周期中数字双胞胎的概念化和应用.
- 为移植中数字双胞胎技术的临床转化提出路线图.
主要方法:
- 针对性的文献搜索 (2025年6月至10月),重点关注移植,机器输液,精确免疫抑制,免疫建模和虚拟器官中的数字双胞胎.
- 优先考虑范围审查,机制研究,临床调查和技术来源.
主要成果:
- 基础应用包括活体捐赠者的虚拟肝脏双胞胎和器官评估的正常热机 perfusion 数据.
- 免疫抑制剂 (例如,塔克罗利斯) 的精确剂量系统和用于排斥预测的免疫系统双胞胎正在出现.
- 证据包括模拟和早期的药理动力学/药理动力学研究,但前性验证有限.
结论:
- 数字双胞胎显示出在整个患者旅程中增强移植决策的重大前景.
- 广泛采用需要严格的验证,可互操作的数据基础设施和强大的治理框架,优先考虑安全和公平.
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