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Updated: Feb 19, 2026

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帕瑟诺利德通过共同向Trim33和抑制NF-κB通路来改善败血症中的炎症

Xueling He¹, Chen Wang², Ruihao Zhang³

¹Ningbo Municipal Hospital of TCM Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315010, China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Guangdong Provincial Key Laboratory of Research and Development in TCM, Guangdong Second Hospital of Traditional Chinese Medicine, Guangzhou 510000, Guangdong, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|February 17, 2026

概括

帕瑟诺利德 (PA) 通过向Trim33蛋白,抑制NF-κB通路并减少炎症,有效治疗败血症. 这项研究揭示了PAPA.

科学领域:

生物化学和分子生物学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

败血症是一种危及生命的疾病,是由不受控制的免疫反应引起的感染.
作为NF-κB抑制剂的帕氏化物 (PA) 已显示出缓解炎症反应的潜力.
了解PA在败血症中的精确抗炎机制对于治疗的发展至关重要.

研究的目的:

在败血症模型中研究帕瑟诺利德 (PA) 的抗炎作用.
通过化学蛋白质组学来识别PA的功能性蛋白质标.
阐明通过PA缓解败血症引起的炎症的分子途径.

主要方法:

在小鼠中通过结和刺穿 (CLP) 诱导败血症;在RAW264.7细胞上使用脂聚糖 (LPS) 建模细胞炎症.
与酶相关的免疫吸收试验 (ELISA) 和H&E染色评估了PA在体内治疗效果.
简化基于氨酸活性的蛋白质概况 (SLC-ABPP) 和蛋白质组学在体外确定了PA的标和途径.

主要成果:

在败血症小鼠中,PA治疗改善了生存率,减少了炎症性细胞因子,并改善了组织损伤.
在LPS刺激的巨细胞中,PA有效抑制了炎症.
化学蛋白组学确定了Trim33作为PA的直接目标,揭示了PA通过稳定Smad4.4来抑制NF-κB通路.

结论:

帕瑟诺利德 (PA) 通过向Trim33,抑制Smad4无化,并抑制NF-κB通路来减轻与败血症相关的炎症.
这些发现为PA在炎症性疾病的潜在临床应用提供了新的见解.
在治疗败血症和相关炎症状况方面,PA显示出显著的治疗潜力.

关键词:

炎症炎症是一种炎症.药理学药理学是指药理学的学科.蛋白质组学是指蛋白质组学.目标识别目标识别传统的中国医学是传统的中国医学.

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