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在儿童严重创伤性脑损伤后的营养干预和结果:系统性审查和元分析

Marina Santschi¹, Karthik Kumar Balasubramanian¹, Jessie Cunningham²

¹Department for Pediatric Critical Care Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

Clinical nutrition (Edinburgh, Scotland)

|February 17, 2026

概括

严重创伤性脑损伤 (sTBI) 的儿童的营养干预表明对结果的影响各不相同. 早期营养可能会改善神经系统的结果,而延迟营养与死亡风险增加有关.

科学领域:

儿科重症监护医药儿科重症监护医药
神经科学是一个神经科学.
代谢障碍代谢障碍代谢障碍

背景情况:

在儿童中,严重的创伤性脑损伤 (sTBI) 破坏了新陈代谢,影响了能量消耗,代谢和脂解.
这些代谢变化可能会阻碍儿科患者的康复.

研究的目的:

研究STBI儿童营养干预措施与患者结果之间的关系.
综合有关不同营养策略有效性的现有证据.

主要方法:

在多个数据库 (MEDLINE,Embase等) 的系统文献搜索. 在2025年3月之前.
包括回顾性队列研究,涉及接受营养干预的患有STBI的儿童 (>1个月).
评估神经/功能结果,死亡率,停留时间和与营养相关的措施;在可行的情况下进行元分析.

主要成果:

包括五项回顾性队列研究;偏差风险显著.
一项研究发现,早期营养干预和改善神经系统的结果之间存在显著的关联.
延迟肠道营养 (>48小时) 显示死亡率的几率比率 (OR) 为2.50;未满足的热量摄入量 OR 为0.94.

结论:

儿科STBI的营养策略必须根据患者的需要进行个性化.
持续监测营养状况对于有效和适当的干预至关重要.
由于现有的不确定性和实践的变化性,需要进一步进行高质量的研究.

关键词:

孩子孩子孩子孩子孩子孩子头部受伤的原因是头部受伤.营养疗法是一种营养疗法.结果的结果.创伤性脑损伤是一种创伤性脑损伤.

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Traumatic Brain Injury l: Introduction

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