卵巢储备减少的妇女的卵细胞质量:不像假设的那样差
En-Qi Yan1, Hong-Xia Chen2, Yuan-Li Li1
1Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Reproductive biomedicine online
|February 17, 2026
概括
卵巢储备减少 (DOR) 不会影响欧卵母细胞的发育率. 患有DOR的妇女面临的挑战是由于胚胎的数量较少,而不是卵细胞质量较低,这会影响成功的受孕.
科学领域:
- 生殖医学和内分泌学.
- 在辅助生殖中遗传学和基因组学.
- 在体外受精 (IVF) 和胚胎发育.
背景情况:
- 卵巢储备减少 (DOR) 是一种影响生育能力的疾病.
- 了解DOR对试管婴儿结果的影响对于患者咨询至关重要.
- 在试管婴儿中,对动脉增生病的植入前遗传检测 (PGT-A) 是一个关键的工具.
研究的目的:
- 为了研究DOR对欧普洛伊德胚胎囊率的影响.
- 为了确定一个euploid胚胎所需的胚胎的数量,在有DOR和没有DOR的妇女.
- 为了比较DOR和非DOR组之间的怀孕结果.
主要方法:
- 在一个中心对803个PGT-A周期 (2016-2024) 进行了回顾性分析.
- DOR是由抗穆勒尔激素 (<1.1 ng/ml) 和/或毛囊数量 (<7) 定义的.
- 根据年龄分层 (<35,35-39,>39岁) 进行比较分析.
主要成果:
- 在DOR和非DOR组之间,欧普洛伊德囊的发病率是可比的.
- 一个euploid胚胎所需的胚胎数量因年龄而异,老年DOR患者的需要更高.
- 怀孕结果后的euploid胚胎转移是相同的两个组.
结论:
- DOR并没有显著改变欧普洛伊德母细胞瘤的发病率或怀孕的结果.
- 对于DOR患者来说,主要的挑战是胚胎数量减少,而不是卵细胞质量.
- 这一发现有助于管理患者的期望,并优化DOR个体的试管婴儿策略.
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