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Updated: Feb 19, 2026

Genome Editing in Mammalian Cell Lines using CRISPR-Cas
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Genome Editing in Mammalian Cell Lines using CRISPR-Cas

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在CRISPR-Cas适应过程中对Cas9介导的预测器选择的结构性见解

Ugne Gaizauskaite1, Giedre Tamulaitiene1, Arunas Silanskas1

  • 1Institute of Biotechnology, Life Sciences Center, Vilnius University, Saulėtekio av. 7, 10257 Vilnius, Lithuania.

Molecular cell
|February 17, 2026
PubMed
概括

克里斯普尔-卡斯适应涉及卡斯9蛋白在选择免疫的外来DNA. 结构研究揭示了Cas9,Cas1-Cas2和Csn2如何形成一个超级复合体,以调解Streptococcus thermophilus中的预空间选择.

关键词:
这是CRISPR的适应.在Cas1-Cas2整合酶中.这就是Cas9的情况.在 Csn2 中.这就是PAMAM.在 PAM 认可中使用 PAM 识别.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.原始空间体相邻的图案收购空间空间 收购空间

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