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在接受内放射治疗的患者中,辐射诱导的脱发:系统性审查

Mostafa Jafari¹, Sare Hosseini², Reza Taleei³

¹Department of Radiologic Technology, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

International journal of radiation oncology, biology, physics

|February 17, 2026

概括

辐射诱导性脱发 (RIA) 是放射治疗的剂量依赖性副作用. 确定头皮剂量值和采用头皮节约技术可以预防永久性脱发,改善患者的生活质量.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
医学物理医学物理

背景情况:

辐射诱导性脱发 (RIA) 是部和头部放射治疗的常见副作用.
RIA可以显著影响患者的生活质量和自我形象,需要确定剂量值和预防策略.

研究的目的:

系统地审查有关临时和永久RIA的辐射剂量值的文献.
评估各种放射治疗技术和预测模型在管理RIA中的有效性.

主要方法:

在PRISMA指导下对报告RIA发生率,严重程度,持久性或头皮剂量在接受外部光束放射治疗的患者的研究进行系统审查.
包括使用基于光子的方法,质子疗法和特殊技术 (如海马节约WBRT) 的研究.

主要成果:

分析了15项研究 (约1500名患者),将头皮剂量指标 (D2%和体积参数) 与RIA严重程度相关联.
暂时的RIA发生在20 Gy左右,而永久的RIA在平均剂量>30-36 Gy或D2%剂量45-50 Gy时观察到.
质子NTCP和gEUD模型显示出强大的预测性能 (AUC为0.8-0.9). 儿科患者在较低剂量 (~21 Gy) 时显示永久性RIA. 头皮节省技术减少了头皮剂量,并保存了头发.

结论:

RIA是一种可重现的,剂量依赖的效应,具有确定的头皮剂量值.
头皮轮,最小化热点和头皮节省技术在临床上是有效的.
整合NTCP建模和QoL评估可以实现个性化风险预测和改善幸存者护理.

关键词:

发症 (alopecia) 是一种发光症.大脑瘤大脑瘤脱发脱发脱发脱发脱发脱发脱发脱发建模建模模型是什么辐射疗法辐射疗法

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