使用0.3%的西达胺化喷雾在牙科植入术后评估疼痛缓解:双盲,随机临床试验
The Journal of oral implantology
|February 17, 2026
概括
0.3%的胺化 (BNZD) 喷雾有效地降低了牙植入手术后的疼痛强度和加速疼痛缓解. 使用BNZD喷雾剂的患者比使用安慰剂的患者更快地达到无痛状态,这表明在术后疼痛管理方面具有临床益处.
科学领域:
- 口腔和牙面部外科手术
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 有效的术后疼痛控制对于牙植入程序后的患者舒适性至关重要.
- 胺化 (BNZD) 是一种抗炎和局部止痛药,具有治疗牙科手术疼痛的潜力.
研究的目的:
- 为了评估与安慰剂相比,0.3%的胺化 (BNZD) 喷雾在单次后部牙植入物放置后的术后疼痛控制方面的疗效.
主要方法:
- 这是一项双盲随机临床试验,涉及30名健康成年人进行牙科植入手术.
- 参与者被随机分配,接受0.3%的BNZD喷雾或安慰剂.
- 在多个时间点使用视觉模拟量表 (VAS) 评估疼痛强度,以及喷雾使用和救援止痛剂摄入量.
主要成果:
- 虽然手术后的疼痛是相似的,但BNZD组在手术后18小时显示出明显的疼痛减轻.
- BNZD组在72小时内达到0的VAS得分,表明疼痛完全消失,而安慰剂组仍然报告疼痛.
- 在BNZD组中观察到喷雾频率明显较低 (P = .03).
结论:
- 0.3%的BNZD喷雾剂可以通过加快疼痛缓解和可能减少牙科植入手术后止痛药的使用来提供临床益处.
- 在BNZD组中早些时候实现无疼痛状态表明其在改善患者结果方面的有用性.
- 建议使用更大的样本大小进行进一步的研究,以验证这些发现.
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