艾滋病毒和心血管疾病:系统审查和比较风险评估研究
Zeyu Luo1,2, Ke Tang1,2, Jiayao Ying1,2
1Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, Hangzhou, China.
BMJ global health
|February 17, 2026
概括
归因于艾滋病毒的心血管疾病 (CVD) 负担在全球范围内显著增加,特别是在非洲地区. 将心血管疾病查整合到艾滋病毒治疗中至关重要,尤其是在高患病率地区.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 携带艾滋病毒 (PLWH) 的人患心血管疾病 (CVD) 的风险要高得多.
- 了解与艾滋病毒相关的心血管疾病的时间趋势和负担对于公共卫生干预至关重要.
研究的目的:
- 量化全球,区域和国家心血管疾病 (CVD) 负担的全球,区域和国家时间趋势,归因于艾滋病毒感染.
- 评估艾滋病毒对各种心血管疾病亚型的影响.
主要方法:
- 对队列研究 (PubMed,Embase,MEDLINE) 的系统文献搜索至2024年10月.
- 随机效应元分析以估计艾滋病毒和心血管疾病的综合风险比率 (RRs).
- 使用2021年全球疾病负担 (GBD) 数据 (2000-2021) 计算人口归因分数 (PAF) 和年龄标准化DALY率 (ASDR).
主要成果:
- 艾滋病毒感染显著增加了总心血管疾病 (RR=1.38),中风 (1.90),缺血性心脏病 (1.72),心脏骤停 (2.58) 的风险.
- 在2000年至2021年期间,全球因艾滋病毒引起的心血管疾病负担几乎增加了三倍,从每10万人口中的3.45增加到9.26.
- 负担在社会人口指数较低的地区,特别是非洲南部,是最高的,其中莱索托和埃斯瓦提尼在2021年显示了最高的比例.
结论:
- 在过去的二十年中,与艾滋病毒相关的心血管疾病负担大幅增加.
- 这种负担明显集中在非洲地区.
- 在高患病率的环境中,迫切需要将心血管疾病查和管理纳入HIV护理.
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