在COVID-19封锁期间,精神困扰的家庭内部动态
Johanne H Pettersen1,2, Espen Eilertsen3, Laura Hegemann4,5
1PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. johannehagen.pettersen@fhi.no.
Translational psychiatry
|February 17, 2026
概括
家庭遗传因素会影响精神困扰,特别是在COVID-19封锁期间. 间接的遗传影响解释了青少年的痛苦 (由母亲驱动) 和父母的痛苦 (由孩子或伴侣驱动).
科学领域:
- 行为遗传学 行为遗传学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 随着COVID-19大流行和相关的封锁,家庭的亲密关系和接触越来越大.
- 在此期间,家庭成员对精神困扰的具体贡献仍然不清楚.
- 了解家庭内的遗传影响对于心理健康研究至关重要.
研究的目的:
- 为了解开父母驱动,儿童驱动和伴侣驱动的遗传贡献在Covid-19封锁期间的精神痛苦.
- 调查核家庭内对心理痛苦的直接和间接遗传影响.
- 检查心理健康状况和家庭成员痛苦的多基因分数 (PGS) 之间的关联.
主要方法:
- 利用了三组全基因组复杂的特征分析,使用来自青少年,母亲和父亲的遗传数据.
- 采用三重多基因分数 (PGS) 设计来评估遗传责任因素及其时间稳定性.
- 分析了对直接遗传影响 (个体对自身痛苦的基因型) 和间接遗传影响 (个体对家庭成员痛苦的基因型) 的差异成分.
主要成果:
- 间接的遗传影响占青少年精神困境的10% (由母亲驱动) 和父亲困境的5% (由儿童驱动).
- 伴侣驱动的间接遗传影响解释了2-3%的母亲精神困扰.
- 母亲的抑郁和ADHD多基因分数与父亲的精神困扰有关;直接的遗传效应解释了9-10%的困扰变异,与焦虑,抑郁,ADHD和神经病症有关.
结论:
- 家庭层面的遗传因素在很大程度上导致精神困扰,有明显的间接影响,从母亲到青少年,从孩子到父亲.
- 直接的遗传影响,部分由常见精神疾病的变体解释,也在个人的精神困扰中发挥着重要作用.
- 调查结果强调了家庭动态在心理健康中的重要性,并表明将家庭成员纳入干预措施的潜在好处.
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