人类白细胞抗原B基因型与埃及患者的COVID-19严重程度的关联
Reham Abdelmonem1, Heba Selim2, Shymaa Abdullah Mohamed3
1Microbiology Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt. reham.h.e@hotmail.com.
Scientific reports
|February 17, 2026
概括
主体遗传学,特别是人类白细胞抗原B (HLA-B) 基因,影响COVID-19的严重程度. 某些HLA-B类型,如HLA-B44和HLA-B08,与更严重的SARS-CoV-2感染和更高的病毒载荷有关.
科学领域:
- 免疫遗传学 免疫遗传学
- 病毒学 病毒学
- 传染病流行病学 传染病流行病学
背景情况:
- 主体遗传因素,特别是主要基因相容性复合 (MHC) 基因,显著影响传染病的临床结果,包括COVID-19.
- 人类白细胞抗原B (HLA-B) 位点对于病原体识别和免疫反应至关重要,使其成为调查COVID-19严重程度变化的关键候选人.
研究的目的:
- 在SARS-CoV-2-阳性患者中识别与严重COVID-19病例相关的特定人类白细胞抗原B (HLA-B) 等位基因型.
- 探索HLA-B等位基因,病毒载荷 (以周期值表示) 和COVID-19疾病严重程度之间的关系.
主要方法:
- 一项涉及2022年11月至2023年4月的SARS-CoV-2阳性患者的横截面研究.
- 通过RT-PCR测定鼻和口腔的病毒载荷 (Ct值).
- 在血液样本上使用INNO-LiPA HLA-B Update Plus套件进行了DNA提取和HLA-B排型.
主要成果:
- 在较低周期值 (Ct) 和严重的COVID-19病例之间发现了显著的关联 (平均Ct = 22.27,p=0.026).
- 鉴定出HLA-B44是与轻度,中度和重度疾病严重程度相关的最显著的等位基因 (p=0.044).
- 当将轻度病例与住院患者进行比较时,HLA-B08和HLA-B44显示出统计学意义 (p=0.011和p=0.034).
结论:
- 周期值 (Ct) 值是SARS-CoV-2感染严重程度的可靠指标.
- 特定的HLA-B等位基因,特别是HLA-B44和HLA-B08,与COVID-19患者的疾病严重程度和病毒载量增加有显著的关联.
- 这些发现支持了个性化COVID-19管理策略和公共卫生干预措施中HLA-B基因定型的潜力.
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