[在瘤中进行定位子发射断层扫描]
Wolfgang P Fendler1, Lukas Kessler2,3, Stephan Himmen2
1Klinik für Nuklearmedizin, Westdeutsches Krebszentrum, DKTK und NCT-Standort, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Deutschland. wolfgang.fendler@uk-essen.de.
Radiologie (Heidelberg, Germany)
|February 17, 2026
概括
针对纤维细胞激活蛋白 (FAP) 的新型成像剂在瘤中比18F-FDG PET/CT.更高的吸收率. FAPI-PET可以改善诊断,并识别患者进行FAP向治疗.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 分子成像学分子成像学
背景情况:
- 瘤是一种罕见的,异质的瘤,需要先进的成像来诊断,分期和监测.
- 18F-Fluorodeoxyglucose (18F-FDG) PET/CT是一种用于高等级瘤的标准工具,有助于风险评估和治疗反应评估.
- 纤维细胞激活蛋白 (FAP) 在许多瘤中具有高度表达,使其成为一个有前途的分子标.
研究的目的:
- 评估68Ga标记的FAP抑制剂 (FAPI) PET与18F-FDG PET/CT相比在肉瘤成像中的实用性.
- 探索FAPI-PET的潜力,以确定符合FAP向放射性连接体治疗 (RLT) 资格的患者.
主要方法:
- 在不同类型的肉瘤亚型中比较FAPI-PET和18F-FDG PET/CT吸收.
- 评估瘤背景对比度和与基因病学FAP表达的相关性.
- 评估FAP-RLT在高级转移性肉 Sarcoma中使用90Y-FAPI-46等放射性连接体的安全性和有效性.
主要成果:
- 在所有类型的瘤中,FAPI-PET的瘤吸收率高于18F-FDG的PET/CT,包括那些18F-FDG度低的瘤.
- FAPI-PET显示出有利的瘤背景对比度,并且与FAP表达良好相关.
- 早期的FAP-RLT在超过一半的晚期转移性肉瘤患者中显示出安全性,可行性和疾病控制.
结论:
- 在特定的肉瘤亚型中,FAPI-PET可能比18F-FDG PET/CT具有优势.
- 在患者选择FAP向治疗方面,FAPI-PET具有前景.
- 需要进一步的前性研究来确定FAPI-PET在个性化肉瘤管理中的作用.
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