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Updated: Feb 19, 2026

Author Spotlight: Enhancements in Gene Expression Regulation Research
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基因组脱甲基酶KDM4B在表观遗传上控制NLRP3的表达,以增强炎症反应

Li Tong1, Hui Song1,2, Yuan Gao1

  • 1Key Laboratory of Infection Immunity and Disease Intervention of Shandong Province, and Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, School of Basic Medical Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

EMBO molecular medicine
|February 17, 2026
PubMed
概括

基因组脱甲基酶KDM4B通过去除H3K9me3标记来加速NLRP3炎症酶激活,提供了一个新的抗炎点. 高葡萄糖加剧了这一过程,在感染期间恶化了炎症.

关键词:
表观遗传修饰是一种表观遗传修饰.H3K9me3是什么意思 H3K9me3是什么意思这就是KDM4B.在NLRP3中,NLRP3是NLRP3中的一个.在 NLRP3 炎症酶体中,NLRP3 炎症酶体是

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