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Updated: Feb 19, 2026

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细胞内DHODH的异位表达从线粒体电子运输中解了新型金胺生物合成

Andrea Curtabbi1, Sara Natalia Jaroszewicz1, Rocío Sanz-Cortés1

  • 1Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.

Nature metabolism
|February 17, 2026
PubMed
概括

将酵母基因 (ScURA) 引入哺乳动物细胞中,将皮里米丁合成与细胞呼吸脱. 这种工程酶使呼吸独立的DNA合成成为可能,并提供对线粒体抑制剂的抗性.

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