前列腺癌的饮食,营养和激素治疗:一个系统的审查,对未来的干预措施产生影响
Isabella Pahulu1, Matthew Calumpit2, Paul Tominez3
1Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.
JNCI cancer spectrum
|February 18, 2026
概括
饮食干预和体重管理策略可以帮助缓解前列腺癌患者的雄激素剥夺疗法 (ADT) 的副作用. 这些营养方法改善了在幸存者护理期间的代谢健康和生活质量.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 雄激素剥夺疗法 (ADT) 对于前列腺癌治疗至关重要,但会导致代谢综合征等不良影响.
- 管理并发症对于接受ADT的前列腺癌患者的生存至关重要.
- 与ADT相关的代谢综合征包括葡萄糖耐受性受损,肌肉质量丧失和体重增加.
研究的目的:
- 系统地审查与ADT相关的副作用的饮食和体重管理干预措施的随机临床试验 (RCT).
- 评估营养策略对前列腺癌患者的生活质量和代谢健康对ADT的影响.
主要方法:
- 根据PRISMA指南,对2015-2025年期间发表的RCT进行系统审查.
- 在PubMed/Embase搜索了包括"前列腺癌"",饮食"",营养"",GLP-1RA"和"ADT"在内的术语.
- 使用ROB2和GRADE工具评估RCT质量.
主要成果:
- 16个RCT符合标准;没有评估GLP-1RA或具有高偏差风险.
- 地中海和低碳水化合物饮食与运动相结合,降低了代谢风险因素.
- 多学科护理和社区支持增强了坚持和长期结果.
结论:
- 营养干预措施是安全的和可行的前列腺癌患者在ADT.
- 对于幸存者护理,可以推饮食策略.
- 未来的研究应该专注于最佳饮食持续时间,更长的随访时间,以及像GLP-1RA这样的新疗法.
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