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评估fraxin在中的抗腹活性:协同效应和分子对接研究

Wahidul Alam^1,2, Salehin Sheikh^1,2, Raihan Chowdhury^1,2

¹Department of Pharmacy, Gopalganj Science and Technology University, Gopalganj, Bangladesh.

Chemical biology & drug design

|February 18, 2026

概括

弗拉辛 (FRX) 在体内和体内表现出显著的抗腹作用,作用于COX-2和MOR受体. 这种天然化合物显示出作为治疗胃肠道疾病的治疗剂的希望.

科学领域:

药理学药理学是指药理学的学科.
自然产品化学化学
胃肠病学胃肠病学

背景情况:

弗拉辛 (FRX) 是一种天然化合物,具有潜在的治疗益处,特别是对于胃肠道疾病.
胃肠道疾病是一个重大的全球健康问题,需要新的治疗策略.

研究的目的:

使用体内和模型研究Fraxin (FRX) 的抗腹活性.
探索潜在的作用机制,包括与COX-2和MOR受体的相互作用.

主要方法:

在活体中,使用麻油和硫酸诱导的腹模型对小的抗腹疗效进行了评估.
在基分子对接研究中进行了评估FRX与COX-2和MOR受体的结合亲和力.
进行了毒性预测,以评估FRX的安全性.

主要成果:

在两种诱导模型中,FRX (5和10 mg/kg) 显著延迟了腹发作和降低了分泌量 (p < 0.05).
结合治疗包括FRX与末亚酸盐 (BSS) 或洛佩拉米德 (LOP) 显示显著增强抗腹抑制 (高达75.93%).
在分析显示,FRX与COX-2 (-8.8 kcal/mol) 和MOR (-7.1 kcal/mol) 受体具有强烈的结合亲缘关系,预测毒性低 (LD50: 5000 mg/kg).

结论:

弗拉辛 (FRX) 具有显著的抗腹特性,得到了体内和体内证据的支持.
FRX的抗腹作用可能通过与COX-2和MOR通路的相互作用来介导.
在治疗胃肠道疾病和与炎症相关的疾病方面,FRX是一个有前途的治疗候选药物.

关键词:

库马林糖化物中的一种.腹腹腹腹腹腹弗拉克辛 (Fraxin) 是一个分子对接的分子对接.植物药理学植物药理学毒性的毒性毒性的毒性

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