使用超临界抗溶剂 (SAS) 方法对β-sitosterol进行沉和封装,用于控制的营养药释放
Daniela Cerro1, Albertina Cabañas2, Alejandra Torres3
1Technology Center for Food Packaging Innovation LABEN-CHILE. CEDENNA-USACH, University of Santiago de Chile, Chile; Laboratory of Membrane Separation Processes (LabProSeM), Department of Chemical Engineering and Bioprocesses, Engineering Faculty, University of Santiago de Chile, Chile; Chemical Engineering and Bioprocess Department, Faculty of Engineering, University of Santiago of Chile, Santiago, Chile.
Food research international (Ottawa, Ont.)
|February 18, 2026
概括
这项研究使用超临界流体技术开发了一种β-sitosterol (βsit) 的受控输送系统. 该过程成功地将βsit与聚卡普罗拉克微化,增强了其用于营养药物的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 食品科学 食品科学 食品科学
背景情况:
- 植物植物的β-sitosterol (βsit) 提供健康益处,但具有较差的溶解性和生物可用性.
- 这些局限性阻碍了其在营养药和功能性食品中的有效使用.
- 开发先进的输送系统对于优化βsit的治疗潜力至关重要.
研究的目的:
- 使用超临界抗溶剂 (SAS) 工艺在聚烯酸盐 (PCL) 中沉和封装βsit.
- 为营养药物生物活性制品创建一个受控的输送系统.
- 为了优化SAS过程条件的βsit沉和微粒形成.
主要方法:
- 超临界抗溶剂 (SAS) 工艺使用超临界CO2作为抗溶剂.
- 在受控的温度和压力下从乙酸乙烯溶液中沉βsit (9MPa被选为最佳).
- 包装βsit与聚氨酸 (PCL) 并评估Tween 80 (T80) 效应.
主要成果:
- 在PCL微粒中通过SAS沉成功微化βsit.
- 确定了 βsit 降水的最佳条件 (9 MPa, 40°C).
- 加入Tween 80 (T80) 提高了整合效率,微粒均性和工艺产量.
- PCL封装减缓了βsit的释放,而T80则加速了它.
结论:
- 该SAS过程是有效的微化βsit和PCL到一个受控的交付系统.
- 配方参数,包括T80,显著影响βsit释放动力学.
- 这项技术显示了增强功能性食品和营养保健品中生物活性化合物的传递的前景.
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