在患有多发性骨髓瘤的患者中,对无症状的生化复发进行达拉图穆马布或积极观察
Krzysztof Jamroziak1, Dominik Dytfeld2, Tadeusz Kubicki2
1Department of Haematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
British journal of haematology
|February 18, 2026
概括
与观察相比,在无症状多发性骨髓瘤生物化学进展方面,早期用达拉图巴治疗显著改善了无事件生存率和整体生存率. 这表明,预防性治疗可以延迟复发并延长患者的寿命.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 多发性骨髓瘤的进展是异质的,通常在器官症状出现之前,有无症状的生化变化.
- 治疗生化进展对长期结果的影响尚不清楚.
研究的目的:
- 评估早期达拉图穆马布单疗法与多发性骨髓瘤无症状生化进展的患者观察的疗效.
主要方法:
- PREDATOR-BR试验是一项随机的多中心研究,涉及92名患者.
- 患者接受了达拉图马布单一治疗或观察.
- 主要终点是无事件生存期 (EFS).
主要成果:
- 达拉图穆马布的EFS中位数为28.9个月,与观察 (HR,0.25) 相比为4.0个月.
- 对达拉图穆马布的应答率为61.0%,对观察的应答率为6.8% (p < 0.0001).
- 在24个月的整体存活率是100%的达拉图穆马布与70.5%的观察 (HR,0.04).
结论:
- 在多发性骨髓瘤无症状生化复发的早期达拉图姆治疗延迟了临床复发.
- 预防性地开始治疗可能会延长患者的生存时间并改善结果.
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