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Updated: Jun 12, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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通过人工智能协助发现和优化具有功能性微质活动的小分子TREM2激动剂

Sungwoo Cho1, Tibor Viktor Szalai2,3, Farida El Gaamouch1

  • 1Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York 10065, United States.

ACS medicinal chemistry letters
|February 18, 2026
PubMed
概括

研究人员开发了一种新的小分子,T2M-010,以激活TREM2 (在骨髓细胞表达的触发受体2). 这种阿尔茨海默病治疗候选药物增强了微质细胞和受体信号传递.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.生物物理验证验证微质细胞中的微质细胞药理动力学 药理动力学在TREM2中,我们可以使用TREM2.

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