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发现了强大,选择性和穿透大脑的小分子CD38抑制剂

Andrew J Stott1, Roland W Bürli1, Kevin J Doyle1

  • 1Cerevance Limited, 418 Cambridge Science Park, Cambridge CB4 0PZ, U.K.

ACS medicinal chemistry letters
|February 18, 2026
PubMed
概括

集群差异化38 (CD38) 酶抑制会提高尼古丁胺氨酸二核酸 (NAD+) 水平,为神经退行性疾病提供潜在的治疗方法. 研究人员开发了脑透抑制剂CVN14,以探索这种治疗途径.

关键词:
CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38 CD38它们是NAD+NAD+NAD.神经退行症的神经退行症小分子抑制剂小分子抑制剂

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