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Updated: May 8, 2026

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
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结构,电子和生物活性分析2'-基基-Ag复合物:DFT支持的一项关于抗癌,抗氧化和抗菌活性的生物医学研究

Ayesha Latif Butt1, Farhat Saira2, Safeer Ahmed1

  • 1Department of Chemistry, Quaid-i-Azam University 45320 Islamabad Pakistan safeerad@qau.edu.pk.

RSC advances
|February 18, 2026
PubMed
概括

这项研究合成了一种新型的-银纳米粒子 (chal-AgNP) 复合物. -AgNP由于其独特的结构和电子性质,表现出增强的抗菌,抗癌和抗氧化活性.

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
The direct-acting...
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Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic antagonists are called...
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Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...