与年龄相关的线粒体能量代谢重编程发生在卵巢衰老期间的颗粒状细胞中
Mengyu Shi1, Zhicheng Jia2, Xinxin Yang1
1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in endocrinology
|February 18, 2026
概括
卵巢衰老将粒粉细胞的新陈代谢从氧化酸化转变为糖解. 这种糖代谢重编程为晚年孕产妇女性的不孕症提供了潜在的治疗点.
科学领域:
- 生殖医学 生殖医学
- 细胞的新陈代谢
- 生物老龄化 生物老龄化
背景情况:
- 卵巢衰老是一种自然过程,影响生育能力.
- 晚期孕产妇年龄 (AMA) 在实现临床怀孕方面存在挑战.
- 了解在衰老过程中颗粒细胞 (GC) 的代谢变化至关重要.
研究的目的:
- 调查在卵巢衰老期间GCs中线粒体能量代谢重编程的机制.
- 为了确定与年轻女性相比,AMA的妇女的GC中的代谢变化.
- 探索氧化应激在GC衰老和代谢功能障碍中的作用.
主要方法:
- 来自接受IVF-ET的年轻和AMA不孕妇女的GC的前性观察研究.
- 在实验室中建立了氧化应激诱导的衰老模型,使用用H2O2.2治疗的KGN细胞.
- 高分辨率的向代谢学分析代谢物变化和线粒体功能.
主要成果:
- 从AMA妇女的GC中,核心能量代谢途径 (OXPHOS,糖解,TCA循环) 的显著调节失调.
- 与年轻组相比,AMA组显示出高调的糖解和低调的OXPHOS/TCA循环中间体.
- 实验室衰老模型证实了糖解 (乳酸盐生产,ECAR) 的增加和OXPHOS (OCR) 的减少,以及mtROS的增加.
结论:
- 在卵巢衰老过程中,花胞细胞重新编程线粒体能量代谢,从OXPHOS转变为糖解.
- 在GC中与年龄相关的糖代谢干扰与AMA中的不孕症有关.
- 针对这些代谢途径可能为AMA不孕症提供新的治疗策略.
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