基于脑成像数据和总结数据的门德尔随机化分析揭示了多器官衰老对精神分裂症的影响
Yan-Kun Han1,2, Miao-Yan Liu2, Ding-Long Yang3
1Department of Psychiatry, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China.
Frontiers in psychiatry
|February 18, 2026
概括
精神分裂症 (SZ) 与全身衰老有关. 这项研究确定了特定的衰老基因和影响SZ风险的途径,BRCA1表达与患者的大脑衰老相关.
科学领域:
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 精神分裂症 (SZ) 呈现出显著的非神经系统性并发症,这表明系统性衰老的参与超出了加速的大脑衰老.
- 连接多系统衰老和精神分裂症的生物机制在很大程度上仍未被探索.
研究的目的:
- 研究与衰老相关的基因与精神分裂症 (SZ) 风险之间的组织特异性遗传联系.
- 为了确定潜在的衰老途径,涉及到SZ发展.
- 探索关键衰老基因与SZ患者大脑预测年龄差异 (PAD) 之间的关系.
主要方法:
- 利用了全基因组关联研究 (GWAS) 的数据,用于SZ相关的SNP,衰老基因数据集和GTEx cis-eQTL数据.
- 采用特定组织的孟德尔随机化 (MR) 和基于总结数据的MR (SMR) 来分析基因表达和SZ风险.
- 在临床患者中进行了丰富分析,以确定衰老途径和与大脑PAD相关的基因表达.
主要成果:
- 确定了特定组织的衰老基因,包括SNCA,ACE,BRCA1,MLH1,VEGFA,MAPT和ARMS2,可能会影响SZ.
- 发现组织特异性cis-eQTLs通过衰老途径影响SZ风险.
- 增加的BRCA1表达与精神分裂症患者大脑预测年龄差异 (PAD) 的较高显著相关.
结论:
- 这项研究为精神分裂症和多系统衰老之间的联系提供了关键的见解.
- 这些发现提高了对特定组织衰老基因的理解,这些基因有助于精神分裂症风险.
相关概念视频
01:29Biological Causes of Schizophrenia
706
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
706
01:26Aging
874
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
874
01:19The Effect of Aging on Tissues
3.8K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.8K