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磁共振成像将良性与恶性骨和软组织瘤区分开来,并使用APT和DWI工具评估Ki-67表达

Xinxin Liu¹, Pengxiang Li¹, Pan Shang¹

¹MRI Department, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China.

Frontiers in oncology

|February 18, 2026

概括

胺基质子转移 (APT) MRI 在区分良性和恶性骨和软组织瘤方面显示出高准确性. APT还与Ki-67表达相关,作为瘤扩散的非侵入性标记物.

科学领域:

放射学和成像学放射学和成像学
在瘤学瘤学.
生物医学工程生物医学工程

背景情况:

由于特异性较低,传统的MRI在区分良性和恶性骨病变方面存在局限性.
胺基质子转移 (APT) MRI是一种新兴的技术,可以检测蛋白质和中的胺基质子.
关于APT在骨和软组织瘤的定性诊断中的应用存在有限的研究.

研究的目的:

评估APT和扩散权重成像 (DWI) 在区分良性和恶性骨和软组织瘤方面的有效性.
评估APT,DWI参数 (ADC,EADC) 和瘤中的Ki-67表达之间的相关性.
为了确定APT和DWI在瘤特征的诊断性能.

主要方法:

49名患有骨或软组织瘤的患者接受了MRI扫描.
测量了APT,显微扩散系数 (ADC) 和指数显微扩散系数 (EADC) 的值.
在成像参数和Ki-67表达之间进行了相关性分析.
接收器操作特征 (ROC) 曲线分析评估了诊断效率.

主要成果:

在良性和恶性瘤之间发现了APT,ADC和EADC值的显著差异 (P < .001,P = .0032,P = .019).
APT显示了与Ki-67表达的正相关性 (r = 0.546,P = .002).
在3.6%的切割值下,APT在区分瘤类型方面实现了72.41%的灵敏度和95%的特异性.

结论:

MR APT 序列在区分良性和恶性骨和软组织瘤方面表现出高的诊断效率.
结合APT,ADC和EADC可以提高诊断特异性.
APT作为一种非侵入性成像标记,用于评估瘤增殖活动,与Ki-67表达相关.

关键词:

酒后驾驶酒后驾驶酒后驾驶在 Ki-67 机器人这就是为什么MRI是MRI.氨基胺质子转移成像技术骨和软组织瘤

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