在接受脏和肝脏移植的人群中出现De Novo慢性鼻炎的发生率和危险因素
Bastien A Valencia-Sanchez1, Hannah Daniel1, Prishae Wilson1
1Department of Otolaryngology-Head and Neck Surgery Mayo Clinic Florida Jacksonville Florida USA.
OTO open
|February 18, 2026
概括
接受和肝移植的人患新发慢性鼻炎的发病率更高. 移植拒绝和额外的器官移植是发展这种疾病的重要危险因素.
科学领域:
- 移植手术 移植手术
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
背景情况:
- 慢性鼻炎 (CRS) 是一种常见的疾病,但其在器官移植受体中的发病率尚未确立.
- 接受和肝移植的人可能因免疫抑制和其他因素而面临更高的风险.
研究的目的:
- 估计和肝移植受体中新发慢性鼻炎 (CRS) 的发生率.
- 为了确定与该人群中CRS发展相关的风险因素.
主要方法:
- 追溯队列研究,包括1459名脏和肝脏移植接受者.
- 排除具有先前存在的鼻病情的患者.
- 耳鼻喉科医生根据ICD-10代码诊断CRS;用于识别预测因子的多变量逻辑回归.
主要成果:
- 新发性CRS的两年发病率在脏接受者中为2.4%,在肝移植接受者中为2.3%.
- 总体发病率 (12.0例/1000人年) 超过了一般人口的估计.
- 移植拒绝 (OR 3.2) 和额外的器官移植 (OR 5.0) 独立地与CRS发展有关.
结论:
- 与普通人群相比,接受和肝移植的人患新发性CRS的发病率更高.
- 移植拒绝和接受额外的器官移植是CRS的重要危险因素.
- 在移植受体中早期识别和管理CRS可能会改善结果.
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