相关实验视频

Updated: Feb 19, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice

Published on: November 29, 2019

感染后的ME/CFS,包括COVID后的ME/CFS中的免疫球蛋白G复合体会破坏细胞能量,改变炎症标志物分泌

Zheng Liu¹, Claudia Hollmann¹, Sharada Kalanidhi²

¹Institute of Virology and Immunobiology, University of Würzburg, Germany.

Brain, behavior, & immunity - health

|February 18, 2026

概括

来自肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 患者的免疫球蛋白会导致内皮细胞的线粒体变化. 这表明IgG在ME/CFS病原和潜在的新疗法中的作用.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
代谢研究研究代谢研究

背景情况:

自身免疫是肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和COVID (PASC) 后急性后续症候群的一个关键特征.
以前的研究表明,免疫球蛋白的被动转移可以诱导类似PASC的症状.
这些免疫球蛋白对细胞的确切作用尚不清楚.

研究的目的:

研究ME/CFS患者免疫球蛋白对内皮细胞功能的影响.
了解IgG在ME/CFS相关细胞功能障碍中的作用.

主要方法:

从ME/CFS患者,多发性硬化症患者和健康对照组中分离出来的免疫球蛋白.
使用质谱学分析了免疫复合物的组成.
评估了线粒体功能和内皮细胞和PBMC中的炎症性细胞因子分泌.

主要成果:

来自ME/CFS患者的IgG诱导了线粒体分裂,并改变了内皮细胞中的细胞能量.
ME/CFS IgG 的 Fab 片段模仿了完整的 IgG 对细胞能量的影响.
ME/CFS和COVID后的ME/CFSIgG触发了不同的细胞因子配置,并显示出独特的免疫复合物组成.

结论:

通过碎片化促进线粒体适应,而不会影响ATP的产生.
这些发现表明IgG在ME/CFS中的病原作用.
突出了针对抗体媒介代谢失调的潜在治疗策略.

关键词:

抗体是对抗体的一种.抗原是一种抗原.免疫球蛋白是一种免疫球蛋白.ME/CFS 的意思是 ME/CFS 的意思.线粒体中的线粒体.在COVID后,我们将继续努力.后病毒性慢性疾病后病毒性慢性疾病

更多相关视频

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

相关概念视频

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...