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Updated: Feb 19, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
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Published on: February 15, 2016

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一种温和且原子效率高的四组分级联策略,用于构建具有生物相关性的4-基诺-2(1H) -one衍生物

Dmitrii A Grishin1, Kseniia I Sharkovskaia1, Ilya G Kolmakov1

  • 1Department of Chemistry, M.V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation.

Beilstein journal of organic chemistry
|February 18, 2026
PubMed
概括

一个新的四组分反应有效地合成了新型的4-基诺林-2 (H) - 1衍生物. 这种可持续的方法为药物发现提供了直接访问有价值的开链利诺 Ester.

关键词:
4-基诺林-2(1H) -一个-一个-一个.梅尔德鲁姆的酸是一种酸.迈克尔的添加 迈克尔的添加它具有抗菌活性,具有抗菌活性.多元组件反应反应多元组件反应ʟ-氨酸的催化作用

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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