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饮食习惯与甲状腺疾病的因果关系:单变和多变的孟德尔随机化研究
Ningwei Wang1, Yunyi Yang1, Jiawen You1
1Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai China.
Food science & nutrition
|February 18, 2026
概括
这项研究探讨了饮食和甲状腺健康,发现奶酪和酒精可以降低甲状腺功能低下的风险. 禽类的摄入可能会增加非有毒的甲状腺结节,而红酒可能会降低风险.
科学领域:
- 营养流行病学 营养流行病学
- 遗传学 遗传学 是一个
- 内分泌学 在内分泌学.
背景情况:
- 饮食习惯显著影响整体健康和疾病发展.
- 现有的研究将一些饮食模式与甲状腺疾病联系起来,但因果证据有限.
- 了解饮食与甲状腺之间的联系对于公共健康至关重要.
研究的目的:
- 研究基因预测的饮食摄入量与甲状腺疾病之间的潜在因果关系.
- 在10种甲状腺疾病中分析了45种不同的饮食习惯.
- 为基于饮食的甲状腺疾病预防策略提供证据.
主要方法:
- 使用孟德尔随机化 (MR) 分析与英国生物银行 (饮食) 和FinnGen (甲状腺疾病) GWAS数据.
- 对于单变量MR (UVMR) 和多变量MR (MVMR) 的独立效应,使用的反变量加权 (IVW).
- 应用了错误发现率 (FDR) 校正和链接不平衡得分回归 (LDSC) 进行可靠的分析.
主要成果:
- 确定了28个潜在的因果关系,其中6个仍然是FDR后显著的纠正.
- 吃饭时食用奶酪和酒精与降低甲状腺功能低下的风险有关.
- 禽类消费与较高的非毒性甲状腺结节风险相关;红酒风险较低.
结论:
- 表明特定的饮食因素 (奶酪,酒精,家禽,红酒) 和甲状腺疾病之间的潜在因果关系.
- MVMR的研究结果表明,家禽消费对结节和有独立的影响.
- 结果是产生假设的,并且需要谨慎解释,因为MR假设和潜在的类型.
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