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优化患者和现场参与SYNCHRONIZETM第三期临床试验计划中的患者和现场参与,通过临床试验模拟来治疗肥胖症的survodutide

Domenica M Rubino¹, Vicki Mooney², Viviënne van de Walle³

¹Washington Center for Weight Management and Research, Arlington, VA, USA.

Contemporary clinical trials communications

|February 18, 2026

概括

临床试验模拟 (CTSs) 涉及肥胖试验参与者和现场工作人员改善了试验设计. 反导致调整访问时间表,虚拟选项和材料,增强未来的肥胖临床试验.

科学领域:

临床试验的设计和方法.
肥胖研究的研究.
患者为中心的结果.

背景情况:

临床试验模拟 (CTS) 是完善临床试验设计的宝贵工具.
肥胖临床试验带来了独特的挑战,这些挑战可以通过模拟来解决.
纳入现场工作人员和参与者反对于有效的试验设计至关重要.

研究的目的:

进行临床试验模拟,用于三项肥胖症上丁的第三阶段试验.
收集参与者和现场工作人员对试验设计和材料的反.
确定肥胖临床试验协议的改进领域.

主要方法:

招募符合SYNCHRONIZE试验的纳入标准的个人 (参与者) 和经验丰富的肥胖试验专业人员 (现场工作人员).
参与者审查了试验设计和面向参与者的材料.
现场工作人员审查了试验设计,并采访了这两组.

主要成果:

总体而言,试验设计得到了现场工作人员和参与者的积极欢迎.
现场工作人员建议预先选和加强参与者参与策略.
参与者的反重点是优化培训,时间承诺和数据收集负担.
建议导致调整访问间隔,虚拟访问选项和参与者材料.
心理支持被认为是有益的,但需要进一步研究才能实施.

结论:

通过CTS,参与者和现场工作人员的投入可以显著改善肥胖临床试验设计.
改进的试验设计可能会导致更强大的数据和可靠的临床发现在肥胖研究.
需要进一步的研究才能有效地在临床试验中实施心理支持.

关键词:

抗肥胖剂抗肥胖剂抗肥胖剂临床试验协议临床试验协议临床试验中的临床试验.葡萄糖受体激活剂葡萄糖受体激活剂类似葡萄糖类-1受体激动剂.肥胖问题肥胖问题体重过重的情况

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