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条件生成扩散模型用于可调节微观结构的3D脊椎骨合成

Xin Wang¹, Gengxin Shi¹, Peiqin Teng²

¹Johns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland, United States.

Journal of medical imaging (Bellingham, Wash.)

|February 18, 2026

概括

这项研究引入了一种新型的条件生成扩散模型,用于创建现实的3D轨道骨结构,具有可调节的微架构特性,包括骨体积分数 (BV/TV),轨道骨厚度 (Tb.Th) 和间距 (Tb.Sp). 该模型准确地生成符合所需结构特征的合成骨样本,为骨研究中的先进应用铺平了道路.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
计算生物学计算生物学

背景情况:

脊椎骨的微观架构对于骨的完整性和功能至关重要.
精确模拟椎骨对于研究和临床应用至关重要.
现有的生成合成脊椎骨的方法可能缺乏对微观结构参数的精确控制.

研究的目的:

开发一种有条件的生成扩散模型,用于合成3D椎骨样本.
为了能够精确控制关键的微观结构指标:骨体积分数 (BV/TV),脊椎骨厚度 (Tb.Th) 和间距 (Tb.Sp).
为了高效地生成可局部调节的微观结构的扩展3D卷.

主要方法:

利用3D隐性扩散与变化自编码器 (VAE) 来进行状斑块表示.
在BV/TV,Tb.Th和Tb.Sp上调节模型以指导微结构合成.
采用移动板块推断方法来生成扩展体积和局部可调节的微结构.
在3551个微CT上进行训练,从大腿骨样本中提取了感兴趣的体积 (VOI).

主要成果:

生成的合成脊椎骨补丁在视觉上与真实的微型CT数据相似.
在目标参数和生成参数之间达到了很高的一致性 (PCC:BV/TV的0.99,Tb.Th的0.97,Tb.Sp的0.95).
在多个推断中 (CV ≤6%) 证明了稳定和一致的微结构指标.
移动板块推断产生了现实的连续结构,具有准确的局部微观结构匹配.

结论:

拟议的模型有效地产生了现实的数字椎骨.
隐性扩散与VAE和移位板机制相结合,克服了用于3D体积合成的内存约束.
条件化机制成功地引导合成到所需的微观结构特征.
潜在的应用包括虚拟临床试验和建立先验先进的图像重建.

关键词:

骨的微观结构骨的微观结构扩散模型的扩散模型.综合合成是一种合成.脊椎骨的骨架骨的骨架骨.虚拟成像是一种虚拟的成像.

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