相关实验视频
Updated: Feb 19, 2026

08:39
A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
2.1K
血液透析后与接入相关的手部功能障碍 接入位置 接入位置
Kyoungrae Kim1, Trace Thome1, Lauren Stone1
1Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Kidney international reports
|February 18, 2026
概括
血液透析接入手术导致慢性病 (CKD) 或末期病 (ESKD) 患者的手部功能障碍,导致肌肉缩和增加接入失败. 早期干预对于更好的结果至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血管外科 血管外科
- 肌肉骨研究 研究
背景情况:
- 与接入相关的手部功能障碍 (ARHD) 在血液透析接入放置后常见于患有慢性病 (CKD) 或末期病 (ESKD) 的患者.
- 虽然ARHD对临床结果和生活质量有负面影响,但其潜在的机制和对准入成熟的影响尚不清楚.
研究的目的:
- 为了研究血液透析接入手术后ARHD的机制.
- 评估ARHD对透析准入成熟失败的影响.
主要方法:
- 一项对39名接受血液透析接入手术的CKD/ESKD患者进行纵向研究.
- 手术前和6周后的功能评估 (握力,手指压力,残疾,灵敏度,感觉).
- 肌肉活检分析 (形态学,线粒体功能,转录学) 和6个月的准入成熟后续.
主要成果:
- 手术后六周,患者的握力 (13.5%),手指压力 (30.6 mm Hg) 显著下降,肢体残疾增加.
- 肌肉组织学显示肌纤维缩 (12%的减少) 与握力损失相关.
- 线粒体含量增加,与手指压力相反相关;转录学显示肌纤维发育基因发生变化.
- 在6个月后,ARHD与无辅助成熟失败的发病率高出~20%.
结论:
- 血液透析接入手术导致CKD/ESKD患者的ARHD,其特征是肌肉缩和改变基因表达.
- ARHD与增加透析接入成熟失败有关.
- 这些发现强调了早期识别和有针对性的干预措施的必要性,以预防ARHD并改善外科治疗的结果.
相关概念视频
Hemodialysis I: Introduction
2.0K
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
2.0K
Hemodialysis II: Procedure and Complications
1.0K
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.0K
Hemodialysis III: Nursing Management
1.1K
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.1K
Dialysis
1.6K
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
1.6K
Dialysis
1.9K
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
1.9K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
975
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
975

