不同的结构性大脑模式及其与执行功能和一般认知能力的关联在认知正常的老年人中
Wenjie Pan1, Cheng Xu2, Cheng Zhu2
1Ruian Fifth People's Hospital, Wenzhou, China.
Frontiers in aging neuroscience
|February 18, 2026
概括
老年人表现出明显的脑结构变化,影响执行功能和整体认知. 这些大脑模式与老年人的认知能力有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知科学 认知科学
背景情况:
- 在健康的老年人中注意到灰质结构的变化.
- 大脑结构,执行功能和老化中的一般认知之间的关系尚未完全理解.
研究的目的:
- 研究老年人的结构性大脑模式,执行功能和一般认知能力之间的关联.
- 为了比较年轻人和老年人的大脑结构和认知功能.
主要方法:
- 119名认知正常的老年人和162名年轻人接受了认知评估和结构性核磁共振.
- 基于表面的形态测量推导出皮质厚度 (CT),表面积 (CSA) 和灰质体积 (GMV).
- 调节调解分析探索了大脑结构,执行功能和一般认知能力之间的关系.
主要成果:
- 与年轻人相比,老年人患有较低的额头CT,并在丘脑和门中减少了GMV.
- 右丘脑的GMV与执行功能有关,这反过来又与一般认知能力有关.
- 执行功能调解了右丘脑GMV对年轻人,但不是老年人的一般认知能力的影响.
结论:
- 在认知上正常的老年人表现出独特的结构性大脑模式.
- 这些大脑模式与衰老中的执行功能和一般认知能力有关.
- 研究结果强调了大脑结构变化与健康衰老中的认知之间的联系.
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