针对与代谢功能障碍相关的脂肪性肝病进行抵抗训练:系统性审查和元分析
Yun Chen1, Xiaoya Qiao1, Xinyi Zou1
1Department of Sport and Health Sciences, Nanjing Sport Institute, Nanjing, China.
Frontiers in physiology
|February 18, 2026
概括
抵抗运动通过降低ALT水平和减少肝脂肪,显著改善了代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的肝脏健康. 这种安全的干预措施为那些无法进行有氧运动的人提供了替代方案.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 运动生理学 运动生理学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是一个日益严重的全球健康问题.
- 对MASLD有效的管理策略至关重要,生活方式干预,如炼,显示出有前途.
- 了解不同运动方式的具体影响对于临床指导至关重要.
研究的目的:
- 系统地评估抵抗运动对MASLD患者关键指标的影响.
- 为了确定抵抗训练在改善肝酶和减少肝硬化症方面的有效性.
- 为了建立MASLD管理的最佳阻力运动参数.
主要方法:
- 对随机对照试验 (RCT) 进行了全面的元分析.
- 在主要数据库 (PubMed,Embase等) 进行了搜索. 在2025年3月之前.
- 质量评估使用了Cochrane风险偏差工具,并使用RevMan 5.3.3进行了元分析.
主要成果:
- 分析了11个涉及395名参与者的RCT.
- 观察到阿氨酸转移酶 (ALT) 水平显著降低 (MD = -4.44 U/L).
- 在八项成像研究中,有七项报告说,肝脏脂肪含量大幅减少,没有严重的不良事件.
结论:
- 抵抗运动是一种有效的干预措施,可以改善MASLD患者的ALT水平和肝硬化症.
- 推剂量:全身,多肌肉训练,8-10次运动,60-80%1RM,≥3次/周,持续≥12周.
- 这种方式是安全和有益的,特别是对于ALT升高或有氧运动不耐受的患者,尽管需要进行更大规模的研究.
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