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通过神经磁盘微环境调节进行椎间盘再生的神经调节生物材料

Ang Li¹, Xiaohu Li¹, Yi Yu¹

¹Department of Orthopedics, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.

Research (Washington, D.C.)

|February 18, 2026

概括

椎间盘退化涉及神经入侵,通过神经微环境相互作用加剧疼痛. 本综述探讨了用于椎间盘修复和再生疗法的神经调节和生物工程.

科学领域:

生物医学工程生物医学工程
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

从历史上看,椎间盘被认为是神经动脉.
病理性神经入侵现在被认为是磁盘退化.
神经微环境相互作用显著恶化退化和疼痛.

研究的目的:

系统地分析神经微环境相互作用在椎间盘退化中的作用.
审查生物工程治疗磁盘退行症的策略.
探索神经调节生物材料用于再生疗法.

主要方法:

在健康和退化的磁盘中讨论神经内置.
关于神经异常生长和疼痛通路的机制的阐述.
对生物工程策略和神经调节生物材料的审查.

主要成果:

退化的磁盘中的神经入侵激活了疼痛通路.
生物工程通过神经调节和微环境调节提供了新的治疗方法.
神经调节生物材料在精密医学方面展现出前途.

结论:

了解神经微环境相互作用对于椎间盘修复至关重要.
生物工程和神经调节的生物材料提供了创新的治疗途径.
本综述为基于神经的椎间盘再生提供了基础.

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