关于保护女性生育能力的临床实践指南
Ningxia Sun1, Haixia Ding2,3, Lingbo Cai4
1Department of Reproductive Medicine, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Frontiers in medicine
|February 18, 2026
概括
本指南在发生性腺毒性治疗之前为女性生育能力保护 (FFP) 提供了建议. 关键建议包括在化疗期间使用随机启动刺激,同时服用莱特和GnRH-agonist,以提高活产率.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 临床指南 临床指南
背景情况:
- 癌症和良性疾病的性腺毒疗法存在不可逆转的卵巢衰竭的风险.
- 女性生育能力保护 (FFP) 对于面临潜在阴性不孕症的女性至关重要.
研究的目的:
- 在临床实践中为FFP提供基于证据的建议.
- 解决有关生育评估,卵细胞/胚胎和卵巢组织冷保存和移植的关键问题.
主要方法:
- 根据世卫组织标准制定临床实践指南.
- 由一个多学科的指导方针开发小组 (GDG) 制定九个关键临床问题.
- 考克伦标准系统审查和GRADE方法用于证据评估.
主要成果:
- 当治疗紧急时,随机启动刺激的有条件认可.
- 强烈推莱特醇同时使用,以控制雌激素水平并降低OHSS风险.
- 卵细胞冷保存对成熟女性的组织来说是偏好较弱的,因为累积怀孕率较高,病率较低.
结论:
- FFP策略应根据个体患者的情况和治疗时间表量身定制.
- 强烈建议在化疗期间同时使用GnRH激动剂,以改善随后的活产率.
- 结合年龄,AMH和AFC的基线生育评估,完善了面临不孕症风险的妇女的咨询.
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