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在细胞癌中与瘤相关的中性粒细胞

Olga V Kovaleva¹, Vasiliy V Sinyov¹, Madina A Rashidova¹

¹Institute of Experimenal Oncology and Carcinogenesis, N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.

Frontiers in immunology

|February 18, 2026

概括

与瘤相关的中性粒细胞 (TANs) 和中性粒细胞外细胞陷 (NETs) 驱动激进细胞癌 (RCC) 的进展和耐治疗性. 针对这些中性粒细胞成分提供了有前途的治疗策略,以改善患者的治疗结果.

科学领域:

瘤学,免疫学,分子生物学

背景情况:

细胞癌 (RCC) 是一种免疫性瘤,瘤相关的中性粒细胞 (TAN) 和中性粒细胞外陷 (NET) 是瘤微环境的关键组成部分.
透RCC的中性粒细胞表现出显著的表型异质性,包括亲瘤和免疫抑制子集,传统的N1/N2分类无法完全解释.
中性粒细胞的两极分化受化学,细胞,炎症,缺氧和瘤变化的影响,导致RCC中主要的前瘤功能.

研究的目的:

审查目前对表型多样性,监管机制以及TAN和NET在RCC中的功能作用的理解.
讨论TAN和NET在RCC中的预后和预测意义.
探索针对RCC中中性粒细胞的新兴治疗策略.

主要方法:

文献综述综合了RCC中TAN和NET的当前知识.
分析表型异质性,调节回路和中性粒细胞的功能程序.
检查临床关联,预后意义和治疗影响.

主要成果:

TANs通过促进T细胞排斥,血管新生, stromal重塑和转移来促进RCC的进展.
NETs有助于血管封闭,转移性传播和免疫抑制,特别是在缺氧和死瘤区域.
高TAN密度和激活标记与侵袭性疾病,复发,低生存率和对疗法的耐药性相关.

结论:

TANs和NETs在RCC中发挥关键的前瘤作用,影响瘤行为和治疗反应.
与中性粒细胞相关的基因特征和与微生物群相关的 stromal 炎症可能作为风险分层的生物标志物.
向化基因通路,补充,NET形成或重新培养中性粒细胞代表了对RCC的有希望的治疗途径.

关键词:

这是一种炎症炎症炎症炎症.具有天生的免疫力.作为一个中性恋者.中性粒细胞外细胞陷细胞癌瘤是细胞癌.

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