对影响结合活产的风险因素的分析,用于IVF/ICSI进行不明原因不孕症的夫妇
Ran Liu1,2,3,4,5,6,7, Tong Wu1,2,3,4,5,6,7,8, Guoyu Ding1,2,3,4,5,6,7
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health Shandong University Jinan Shandong People's Republic of China.
Reproductive medicine and biology
|February 18, 2026
概括
无法解释的不孕不育 (UI) 风险因素包括晚年女性年龄,较高的BMI和较低的抗米勒尔激素 (AMH). 识别这些因素可以改善接受体外受精/细胞内精子注射 (IVF/ICSI) 的夫妇的结果.
科学领域:
- 生殖医学 生殖医学
- 不孕症研究 不孕症研究
- 辅助生殖技术 辅助生殖技术
背景情况:
- 无法解释的不孕不育 (UI) 影响了相当一部分不孕不育的夫妇.
- 确定特定的风险因素对于改善治疗结果至关重要.
- 常用的是辅助生殖技术,如体外受精/细胞内精子注射 (IVF/ICSI).
研究的目的:
- 为了确定与第一次试管婴儿/ICSI周期的夫妇中无法解释的不孕症 (UI) 相关的特定风险因素.
- 分析这些因素对活产率的影响.
主要方法:
- 追溯的队列研究,5465个不育夫妇接受了他们的第一个试管婴儿/ICSI周期.
- 多变量后勤回归分析以确定活产的预测因素.
- 分析的重点是人口,荷尔蒙和身体特征.
主要成果:
- 在UI患者中活产的关键负面预测因素包括:女性年龄≥35岁,男性年龄,女性BMI≥27.5 kg/m2,低抗穆勒尔激素 (AMH<1.2 ng/mL) 和中等范围的子宫内膜厚度 (0.7-1.0 cm).
- 提取的卵细胞数量较多与累积活产 (CLB) 有积极的相关性.
- 在一个完整的试管婴儿/ICSI周期后,累计活产率为62.2%.
结论:
- 女性年龄和卵巢储备指标是影响UI患者卵细胞产量,胚胎发育和活产结果的主要因素.
- 了解这些风险因素可以帮助优化生育治疗.
- 在受研究的人群中,UI的患病率为8.8%.
相关概念视频
01:24In Vitro Fertilization
1.1K
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
1.1K
01:28Infertility in Females
4.9K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
4.9K
01:23Infertility in Males
599
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
599
01:26Factors Affecting the Risk of Infection
13.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.9K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
488
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
488
01:22Birth Control Methods
6.9K
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
6.9K