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Updated: Feb 19, 2026

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USP10 降低MTX2的含量,以抑制MI中的cGAS-STING信号

Guo-Jun Zhao1, Hui-Ting Shi1, Xiaoxu Tian1

  • 1Department of Cardiology (G.-J.Z., H.-T.S., X.T., L.K., H.L., G.L., H.T., Y.Z.), The First Affiliated Hospital of Zhengzhou University, China.

Circulation research
|February 18, 2026
PubMed
概括

通过抑制cGAS-STING通路,USP10 (ubiquitin-specific peptidase 10) 通过抑制cGAS-STING通路来保护心肌梗塞 (MI) 后的心脏损伤. 恢复边界区域心肌细胞中的USP10水平为MI提供了潜在的治疗策略.

关键词:
细胞死亡是细胞死亡.心脏衰竭是因为心脏衰竭.缺氧 缺氧是指缺氧的情况.突变发生的突变发生.蛋白质的稳定性 蛋白质的稳定性

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