免疫检查点抑制剂用于治疗Periorbital非黑色素瘤皮肤癌
Niloufar Bineshfar1, Leo Meller2, Andrew J Rong1
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Seminars in ophthalmology
|February 18, 2026
概括
抗编程死亡 (PD-1) /PD-L1免疫疗法在晚期皮质非黑色素瘤皮肤癌 (NMSCs) 中显示出前景. 当其他疗法失败时,Cemiplimab在治疗基底细胞癌 (BCC) 和状细胞癌 (SCC) 中有效.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 皮肤病学 皮肤病学
背景情况:
- 周眼区域的非黑色素瘤皮肤癌 (NMSCs),包括基底细胞癌 (BCC) 和状细胞癌 (SCC),带来了重大的临床挑战.
- 局部发达的周期性NMSC通常需要多模式治疗方法.
研究的目的:
- 评估局部发达周期性NMSCs患者的抗编程死亡 (PD-1) /PD-L1免疫疗法的结果.
- 评估免疫检查点抑制剂在挑战性皮肤癌患者小组中的有效性.
主要方法:
- 一项回顾性研究分析了9名在2016年1月至2023年1月期间用抗PD-1/PD-L1药物治疗的局部晚期周周BCC或皮肤SCC患者.
- 对临床和组织学数据进行了患者记录的审查,并评估了治疗的有效性.
主要成果:
- 四名患者患有周期性BCC,5名患有皮肤性SCC;大多数患者先前接受过治疗.
- 抗PD-1/PD-L1治疗在两个BCC和两个SCC病例中是有效的,所有响应者都使用了CEMIPLIMAB治疗.
- 治疗包括塞米普利马布,尼沃卢马布和潘布罗利祖马布,其中一名患者接受了这三种药物.
结论:
- 抗PD-1/PD-L1免疫疗法,特别是CEMIPLIMAB,对于局部发达的周期性BCC和SCC是一种有前途的治疗方法,特别是在传统疗法失败后.
- 使用更大的队列和多机构合作的进一步研究是有必要的,以验证这些发现,并探索辅助免疫治疗的作用.
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