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在线混合低剂量配方的功效测量使用在旋转平板压力机的料框架中的新型深紫外线LIF探测器

Louis Bouckaert1, Rohit Bhartia2, Zhenqi Shi3

  • 1Laboratory of Pharmaceutical Technology, Ghent University, Ottergemsesteenweg 460, Ghent 9000, Belgium.

Analytical chemistry
|February 18, 2026
PubMed
概括

一个新的深紫外光诱导光 (LIF) 传感器有效监测低剂量配方中的活性药物成分. 这种过程分析技术 (PAT) 工具对连续制造具有前景,克服了当前方法的灵敏度限制.

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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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