高流氧疗法与低压支通风相比,用于自发呼吸试验:一个双中心,非劣势,随机对照研究
Apinut Jaroonpipatkul1, Pichaya Kaeoperm2, Nattapol Promlee1
1Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
高流氧疗法 (HFOT) 与低压支持通风 (PSV) 在自发呼吸试验 (SBT) 中同样有效. 与PSV相比,HFOT还显示了医院死亡率的显著降低.
科学领域:
- 临界护理医学 临界护理医学
- 呼吸系统疗法 呼吸系统疗法
背景情况:
- 低压支通风 (PSV) 是自发呼吸试验 (SBT) 的标准.
- 高流氧疗法 (HFOT) 通过内管为SBTs提供了一个潜在的替代方案.
研究的目的:
- 为了比较使用HFOT的SBT与低级别PSV的成功率.
- 评估输出管和再输入管率以及医院死亡率作为次要结局.
主要方法:
- 进行了一项双中心,开放标签,非劣势随机对照试验.
- 162名成年机械呼吸患者接受了30分钟的SBT,使用HFOT或低水平PSV.
- 主要结局是SBT成功率;次要结局包括输出管/再输入管率和医院死亡率.
主要成果:
- 在HFOT和低级别PSV之间,SBT的成功率不低于HFOT (95.1%在两组中).
- 在输出管或48小时再输入管率方面没有发现显著差异.
- 与低水平PSV组 (24.7%) 相比,HFOT组 (11.1%) 的医院死亡率明显较低.
结论:
- 在机械通风患者中,HFOT是SBTs低水平PSV的非劣质替代品.
- HFOT可能为生存带来好处,需要进一步调查.
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