碳点纳米粒子作为多功能光探针:从可调节合成到生物医学应用
Ahmed Mohammed Ali Abdulkhaleq1,2,3, Zhonghua Jiang1,2,4, Hai Chen1,2,4
1Department of Pulmonary and Critical Care Medicine, Molecularly Targeted Research and Development Laboratory, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China. wuyumao@scu.edu.cn.
Journal of materials chemistry. B
|February 18, 2026
概括
碳点 (CD) 是用于生物医学应用的多功能光纳米材料,如生物成像和生物传感. 本综述强调了它们的合成,机制,疾病应用和未来方向,同时指出了可再生性和生物相容性方面的挑战.
科学领域:
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 碳点 (CD) 是新兴的光纳米材料,具有出色的光学性能,生物相容性和易于合成.
- 它们的独特特性使得它们非常适合用于生物成像,生物传感和生物医学中的诊断.
- 最近的进展表明,CD从实验室研究过渡到实际的生物医学工具,特别是实时应用.
研究的目的:
- 审查碳点的合成和光机制的最新进展.
- 专注于CD的应用,作为针对各种分析物和细胞器官的光探针.
- 批判性地评估CDs在诊断和监测关键疾病中的作用.
主要方法:
- 总结最近关于碳点合成和光机制的文献.
- 分析CD的分类,并将合成参数与光学性能相关联.
- 评估CDs在各种疾病领域的应用,包括瘤学和神经退行性疾病.
主要成果:
- 磁盘显示出作为光探针的有望性,用于金属离子,ROS,酶和生物分子等分析物.
- 应用范围包括早期诊断,治疗监测和在癌症和心血管疾病等疾病中的手术内指导.
- 可持续的合成方法和计算工具 (AI/ML) 正在出现,用于优化CD.
结论:
- 碳点为生物医学应用提供了巨大的潜力,特别是在光探测和疾病管理方面.
- 在合成可再生性,选择性增强和体内生物相容性验证方面仍然存在挑战.
- 跨学科的合作和先进的工程对于基于CD的探针的临床翻译至关重要.
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