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核糖体需求将转录突发与蛋白质表达噪声联系起来

Sampriti Pal¹, Upasana Ray¹, Riddhiman Dhar¹

¹Department of Bioscience and Biotechnology, IIT Kharagpur, Kharagpur, India.

|February 18, 2026

概括

蛋白质表达噪声是细胞变异的来源,与转化效率有关. 高效基因对核糖体的高需求驱动了这种噪音,特别是在爆发式转录中,揭示了分子调节机制.

科学领域:

分子生物学分子生物学
系统生物学系统生物学
遗传学是一个遗传学.

背景情况:

蛋白质表达的随机变化 (表型异质性) 影响抗生素持久性,瘤生长和治疗耐药性.
虽然转录噪声得到了充分的研究,但翻译在调节蛋白质噪声和细胞异质性方面的作用越来越被认可.
跨生物体存在翻译效率和蛋白质噪声之间的正相关性,但其分子基础尚不清楚.

研究的目的:

阐明翻译效率与蛋白质噪声之间的关联的分子基础.
为了研究基因编码序列和促进子活动如何影响蛋白质表达噪声.
了解翻译在产生表型异质性的作用.

主要方法:

在单个mRNA分子水平上对翻译动态的随机建模.
在细胞群中对蛋白质噪声的实证测量.
分析翻译效率,核糖体需求和基因转录模式 (爆发性与非爆发性) 之间的关系.

主要成果:

一个基因的高翻译效率增加了核糖体需求,这推动了翻译效率和蛋白质噪声之间的相关性.
这种相关性特别在表现出爆发性转录模式的基因中观察到.
该研究确定了编码序列和促进体特征作为蛋白质噪声的关键调节者.

结论:

受翻译效率和转录破裂性影响的核糖体需求是将翻译效率与蛋白质噪声联系起来的分子驱动因素.
了解这些调节机制对于破译生物系统中的表型异质性至关重要.
研究结果提供了对控制蛋白质噪声及其在各种生物环境中的影响的见解.

关键词:

它们中的一种是S. cerevisiae.计算生物学是计算生物学.蛋白质表达噪声是一种噪声.核糖体对核糖体需求的需求系统生物学系统生物学转录性爆发是转录性的爆发.翻译爆发是指翻译的爆发.翻译效率的翻译效率

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