关闭后的肌肉复氧化动力学和氧化物的生物可用性,在10天的床上休息后
Giorgio Manferdelli1,2, Letizia Rasica3, Andrea M Pilotto4
1Institute of Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.
概括
十天的卧床休息 (BR) 并没有损害肌肉微血管功能,但确实降低了血中酸盐水平,表明氧化 (NO) 生物可用性的潜在变化.
科学领域:
- 身体生理学 身体生理学
- 心血管科学 心血管科学
- 太空医学 太空医学
背景情况:
- 床上休息 (BR) 研究揭示了不活动对心血管功能,微血管反应能力和氧气提取的有害影响.
- 短期BR对微血管功能及其分子媒介氧化 (NO) 的影响仍然不完全理解.
研究的目的:
- 为了研究10天水平卧床休息 (BR) 对人类骨肌肉中微血管反应效应的影响.
- 评估血中酸盐和酸盐度的变化,作为短期BR后氧化 (NO) 生物可用性的指标.
主要方法:
- 9名健康的男性接受了10天的水平床休息.
- 使用近红外光谱仪测量了巨大的横向肌肉和直骨肌肉中的微血管封闭后反应性高血压.
- 血中酸盐 (NO2-) 和酸盐 (NO3-) 度被量化以评估NO的生物可用性.
主要成果:
- 在两种测量肌肉中,肌肉脱氧率 (Slope 1) 和再输血半倍时间 (t1/2) 在BR后显著减慢 (p<0.05).
- 在BR之后,正常化的微血管响应 (K/Δ[脱氧(Hb+Mb) ]峰值) 保持不变.
- 血亚酸盐 (NO2-) 度在BR后显著下降 (p=0.011),而酸盐 (NO3-) 度没有显著变化.
结论:
- 十天的水平床上休息不会损害骨肌肉中微血管封闭后反应性高血压的基本参数.
- 尽管保持了微血管反应,但短期的BR导致血中酸盐的减少,这表明它可能对氧化 (NO) 的生物可用性产生影响.
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