一个激活的巨细胞的粘性记忆
Luca Frosio1,2, Renato Ostuni1,2
1Vita-Salute San Raffaele University , Milan, Italy.
The Journal of experimental medicine
|February 18, 2026
概括
天生的免疫细胞通过持续的信号记住过去的感染. 细胞表面的细胞因子保留意外地延长了这些训练有素的免疫状态.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 天生的免疫细胞具有记忆能力,保留了先前刺激的分子印记.
- 训练免疫描述了天生的免疫系统在与病原体的二次接触时表现出增强反应的能力.
研究的目的:
- 为了阐明训练有素的免疫状态在最初的刺激已经消退后被维持的机制.
- 研究细胞因子在维持长期免疫记忆中的作用.
主要方法:
- 戈林等人进行的研究. 研究了持续免疫记忆背后的分子机制.
- 专注于干扰素- (IFN-γ) 的作用及其信号通路.
主要成果:
- 一个新的机制揭示了干扰素- (IFN-γ) 维持训练有素的免疫状态.
- 这种长时间的信号传递是由细胞表面保留细胞因子所驱动的,从而延长了免疫记忆效应.
结论:
- 细胞表面的细胞因子保留是维持训练有素免疫力的关键机制.
- 这一发现为长期调节先天性免疫反应提供了新的见解.
相关概念视频
Immune Surveillance by NK Cells and Phagocytes
8.9K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
8.9K
Cell-mediated Immune Responses
84.6K
Overview
84.6K
Cells of the Adaptive Immune Response
9.2K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.2K
Phagocytosis of Apoptotic Cells
5.3K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or immature dendritic cells. Non-professional phagocytes such as epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes.
Normal cells contain receptors that prevent them from being recognized...
Normal cells contain receptors that prevent them from being recognized...
5.3K


