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对与胃癌相关的代谢物现有证据的系统审查

Tung Hoang^1,2,3,4, Pekka Keski-Rahkonen⁵, Mazda Jenab⁵

¹Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.

Journal of the National Cancer Institute

|February 18, 2026

概括

循环中的代谢物显示为胃癌 (GC) 风险和早期检测的生物标志物具有前途. 然而,研究异质性需要标准化的方法来可靠地发现和验证生物标志物.

科学领域:

生物化学生物化学
在瘤学瘤学.
生物标志物发现发现

背景情况:

晚期胃癌 (GC) 诊断导致预后不佳.
循环中的代谢物正在成为GC风险分层和早期检测的潜在生物标志物.
本系统性审查检查了代谢物与GC和癌前胃病变的相关性.

研究的目的:

系统地审查调查循环代谢物和胃癌 (GC) 之间的关联的研究.
探索代谢物在GC风险分层和早期检测中的作用.
确定癌前胃病变和GC的潜在生物标志物.

主要方法:

在PubMed,Embase和Web of Science (2004-2025) 的综合文献搜索.
包括评估内源代谢物 (质谱/NMR) 与GC,癌前病变或亚型相关的研究.
关于研究设计,生物标本,分析方法,H. pylori状态,代谢物和模型性能的数据提取.

主要成果:

包括52项研究:12个仅为病例,31个病例对照,5个嵌套病例对照,4个队列.
在GC和非GC组之间的不同代谢物涉及葡萄糖,脂质,氨基酸,核酸和维生素代谢.
基于代谢物的模型在区分GC和分类疾病阶段方面表现不同;观察到显著的异质性.

结论:

代谢物与GC的关联以及癌前病变的进展为胃癌发生提供了洞察力.
研究中的大量异质性强调了对标准化方法的需求.
在大型多人群研究中进行独立验证对于可靠的生物标志物开发至关重要.

关键词:

胃癌胃癌是一种胃癌.代谢产物的代谢产物代谢生物组的代谢生物组系统性审查系统性审查

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