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慢性和反复性皮肤植物病的临床和真菌学概况: Türkiye, 2022-2024年

Murat Durdu¹, Hazal Kandemir^2,3, Ayşe Sultan Karakoyun⁴

¹Department of Dermatology, Dr. Turgut Noyan Application and Research Center, Başkent University, Adana, Turkey.

|February 18, 2026

概括

慢性真菌性皮肤感染通常对标准治疗有抗性. 这项研究发现了Trichophyton indotineae中的特定基因突变,这表明像白醇和黄素这样的新治疗策略可能是有效的.

科学领域:

菌类学菌类学是指菌类学.
皮肤病学皮肤病学
分子生物学分子生物学

背景情况:

慢性和复发性皮肤植物病构成了重大治疗挑战.
新兴的抗真菌耐药性需要了解潜在的分子机制.
三植物 (Trichophyton indotineae) (原名T. mentagrophytes ITS基因型VIII) 越来越多地与难以治疗的感染有关.

研究的目的:

为了研究慢性皮肤植物病患者的治疗结果.
分析致病性皮肤细胞的体外抗真菌敏感性和烯环氧化酶 (SQLE) 替代性概况.
确定对抗性真菌感染的潜在新型治疗辅助剂.

主要方法:

使用测序对真菌分离物的分子鉴定.
对烯环氧化酶 (SQLE) 基因替代的分析.
根据EUCAST指南进行抗真菌敏感性测试.
临床评估患者对各种抗真菌方案的治疗反应.

主要成果:

三植物 (Trichophyton indotineae) (TmVIII) 是主要的分离物 (76/91).
在TmVIII中发现了常见的SQLE替代物 (Phe397Leu,Tyr414His),观察到五种新型替代物.
特尔比纳和可纳的高最低抑制度 (MIC) 在大多数TmVIII分离物中表明了耐药性.
大多数患者 (83/91) 对标准抗真菌疗法有反应.
复星的辅助疗法在28/29名患者中显著改善,而黄素在3/3名患者中取得了成功.

结论:

在局部TmVIII分离物中,特定的SQLE替代物普遍存在,与抗真菌耐药性相关.
与SQLE测序相结合的EUCAST MIC测试对于对抗性皮肤细胞的监测至关重要.
Resveratrol和黄素作为对抗特尔比纳耐药的T. indotineae感染的辅助疗法具有前景,需要进一步研究.

关键词:

一个人的能力.这种植物是Trichophyton indotineae.抗真菌耐药性的抗真菌耐药性库尔库明是一种黄素.皮肤植物病 (dermatophytosis) 是一种皮肤病.复星醇是一种

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