病原性病毒在东北亚的风险:基因组和生态建模研究
Moujian Guo1, Hengcong Liu2, Hong Zhou3,4,5
1Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Science China. Life sciences
|February 18, 2026
概括
病原性传播病毒 (TBV) 在东北亚是一个显著的,被低估的风险. 这项研究确定了六种感染人类的结核病毒,预测了该地区更广泛的分布和大量的人口影响.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 东北亚的病原性传播病毒 (TBV) 在流行率,病史和疾病风险方面了解甚少.
- 在这个地区,的多样性和病毒活动热点并未得到很好的定义.
研究的目的:
- 在中国东北地区识别和描述传播病毒.
- 模拟东北亚主要感染人类的TBV的生态分布和潜在的人类影响.
主要方法:
- 收集了来自中国东北部不同生态环境的12,000多只.
- 测序和组装病毒基因组,识别了44种TBV,包括6种人类/哺乳动物感染型.
- 对7种感染人类的TBV及其病媒介进行了生态建模.
主要成果:
- 鉴定了六种感染人类/哺乳动物的结核病毒:阿隆山病毒,北奈洛病毒,穆卡瓦病毒,努明病毒,传染性脑炎病毒 (TBEV) 和耶佐病毒.
- 预计TBV和载体的更广泛分布,包括新发现的湿地病毒 (WELV).
- 预测严重发烧与血小板缺血综合征病毒和TBEV在东北亚国家的人口影响显著.
结论:
- 中国东北部和邻近国家是多种感染人类的结核病病毒的高风险地区.
- 目前对结核病毒分布和风险的理解被低估了.
- 优先考虑高风险TBV的预防和治疗措施至关重要.
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